{"id":6625,"date":"2017-01-20T08:26:41","date_gmt":"2017-01-20T08:26:41","guid":{"rendered":"http:\/\/old.institutcataladelpeu.com\/?p=6625\/"},"modified":"2017-03-06T12:29:18","modified_gmt":"2017-03-06T12:29:18","slug":"the-neurofibromatosis-causes-detection-and-treatment","status":"publish","type":"post","link":"https:\/\/old.institutcataladelpeu.com\/en\/the-neurofibromatosis-causes-detection-and-treatment\/","title":{"rendered":"THE NEUROFIBROMATOSIS. CAUSES, DETECTION AND TREATMENT."},"content":{"rendered":"

The neurofibromatosis is an alteration of the nervous system which affect directly in the growth and development of neural cells.<\/p>\n

These alterations cause the development of tumors in nerves, as well as osseous deformities and changes in the skin. These tumors are not usually malignant, although they can cause serious aesthetic problems. They are genetically transmitted in an autosomal way, reaching 50 % of probabilities of passing on the disease from parents to children. They are classified in type 1 or type 2 depending on the alterated chromosome.<\/p>\n

The type 1 neurofibromatosis or Recklinghausen\u2019s disease is one of the most frequent genetic diseases and it shows a wide clinical manifestation.<\/p>\n

In the past, the type 1 neurofibromatosis was known as peripheral neurofibromatosis because there were symptoms like tumors and cutaneous spots\u00a0 which were connected to the peripheral nervous system. Nowadays, it isn\u2019t known with this name, because it is proved the existence of tumors in the central nervous system. Its main feature is the appearance of \u201ccaf\u00e9 au lait spots\u201d, long bones dysplasias, cataracts, etc.<\/p>\n

The type 2 neurofibromatosis is characterized by the predominance of tumors in cranial nerves.<\/p>\n

The cause of the neurofibromatosis is\u00a0 the mutation in the type 1 of the 17th <\/sup>chromosome, whereas in type 2 the mutation is in the 22nd <\/sup>chromosome.<\/p>\n

50 % of neurofibromatosis are produced by a spontaneous mutation.<\/p>\n

The type 1 neurofibromatosis is diagnosed when there are two or more than two of the following symptoms:<\/p>\n

    \n
  1. Parents, brothers or sisters affected by the type 1 neurofibromatosis.<\/li>\n
  2. Axillary or inguinal freckles.<\/li>\n
  3. The existence of two or more than two neurofibromas.<\/li>\n
  4. The existence of six or more than six \u201ccaf\u00e9 au lait spots\u201d bigger than 5 milimeters of diameter before puberty or bigger than 15 milimeters after puberty.<\/li>\n
  5. Gliomas in optical tracts.<\/li>\n
  6. The existence of a peculiar osseous lesion.<\/li>\n
  7. The existence of two or more than two Lisch nodules.<\/li>\n<\/ol>\n

    The type 2 neurofibromatosis like the type 1 neurofibromatosis must consider two or more than two symptoms:<\/p>\n